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Head and Neck Cancer: Building the Evidence Base for Precision Oncology
Caption: Triple immunohistochemical stained oral squamous cell carcinoma: nuclei in brown, cytoplasm in red, and cytoplasmic membranes in blue green.Credit: Alfredo A. Molinolo, Oral and Pharyngeal...
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Precision Medicine: Who Benefits from Aspirin to Prevent Colorectal Cancer?
In recent years, scientific evidence has begun to accumulate that indicates taking aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) on a daily basis may lower the risk of developing...
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Knocking Out Melanoma: Does This Triple Combo Have What It Takes?
It would be great if we could knock out cancer with a single punch. But the more we learn about cancer’s molecular complexities and the immune system’s response to tumors, the more it appears that we...
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What Is Obesity? Metabolic Signatures Offer New Comprehensive View
Credit: Adapted from Elliott, P et al., Sci Transl Med. 2015 Apr 29;7(285) As obesity has risen in the United States and all around the world, so too have many other obesity-related health conditions:...
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Hitting the Right Target? Lab Studies Suggest Epigenetic Drug May Fight...
Caption: Remembering a few of the many children who’ve died of DIPG; Left, Lyla Nsouli and parents; upper right, Andrew Smith and mom; lower right, Alexis Agin and parents.Credits: Nsouli, Smith, and...
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Targeting Cystic Fibrosis: Are Two Drugs Better than One?
Caption: Doctor with a child with cystic fibrosis who is taking part in clinical research studies. Credit: Colorado Clinical and Translational Sciences Institute To explain the many challenges involved...
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Creative Minds: Building a Better Electronic Health Record
Stock photo Is 5 too few and 40 too many? That’s one of many questions that researcher David Chan is asking about the clinical reminders embedded into those electronic health record (EHR) systems...
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A Surprising Match: Cancer Immunotherapy and Mismatch Repair
How Anti-PD-1 Immunotherapy Works. Before immunotherapy (top), the tumor cell’s PD-1 ligand, or PD-L1, molecule (red) binds to a type of white blood cell called a T-cell in a way that enables the tumor...
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Blood Sugar Control for Diabetes: Asking the Heart Questions
Credit: Thinkstock When most people think about risk factors for cardiovascular disease, they likely think of blood pressure readings or cholesterol levels. But here’s something else that should be...
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Precision Oncology: Creating a Genomic Guide for Melanoma Therapy
Caption: Human malignant melanoma cell viewed through a fluorescent, laser-scanning confocal microscope. Invasive structures involved in metastasis appear as greenish-yellow dots, while actin (green)...
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Bold Blueprint for Precision Medicine Initiative’s Research Cohort
Caption: #PMINetwork Twitter chat with @NIHDirector Francis Collins, NIH Media Branch’s @RenateMyles, and, in background, PMI Cohort Program Acting Director @NCCIH_Josie Briggs.Credit: @KathyHudsonNIH...
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Big Data Study Reveals Possible Subtypes of Type 2 Diabetes
Caption: Computational model showing study participants with type 2 diabetes grouped into three subtypes, based on similarities in data contained in their electronic health records. Such information...
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Happy New Year … and a Look Back at a Memorable 2015
A new year has arrived, and it’s going to be an amazing one for biomedical research. But before diving into our first “new science” post of 2016, let’s take a quick look back at 2015 and some of its...
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Taking Control: Learn More About Accessing Your Health Information
Credit: Lydia Polimeni, NIH Usually, I share cool science advances and major medical breakthroughs on this blog. But, today, I’d like to share something a little different, something of great...
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DNA Barcodes Could Streamline Search for New Drugs to Combat Cancer
A little more than a decade ago, researchers began adapting a familiar commercial concept to genomics: the barcode. Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we...
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Happy New Year: Looking Back at 2016 Research Highlights
Happy New Year! While everyone was busy getting ready for the holidays, the journal Science announced its annual compendium of scientific Breakthroughs of the Year. If you missed it, the winner for...
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Got a Great Research Idea? “All of Us” Wants to Hear It!
One of the boldest undertakings that NIH has ever attempted, the All of Us Research Program has been hard at work in a “beta” testing phase, and is now busy gearing up for full recruitment in the...
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